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KMID : 0363620050260010076
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Journal of Korean Oriental Medicine
2005 Volume.26 No. 1 p.76 ~ p.84
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Effects of Galhwahyejung-tang (GHT) on Protection for Alcohol-induced Liver Injury
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Ahn TK
Shin JW/Cho CK/Cho JH/Yoo HS/Lee YW/Lee NH/Yun DH/Son CG
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Abstract
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Objective: The purpose of this study was to examine the protective efficacy of GHT on alcoholic liver injury.
Methods: We measured the rate of alcohol oxidation, serum level of liver enzyme, lipid peroxidation level in liver tissue, and inflammatory related cytokine expressions in the liver.
Results: GHT showed liver protective effects, lowered the levels of AST and LDH in serum and inhibited lipid peroxidation in liver tissue, and enhanced alcohol oxidation. GHT treatment up-regulated IL-10 in the liver, whereas it downregulated $TNF-\alpha,\;TGF-\beta$, and Fas ligand.
Conclusion: From these results, GHT is presumed to work in the liver in protective roles not through the pathway of alcohol metabolism but mainly by anti-inflammation activity in our model.
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KEYWORD
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